Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sedatives and Hypnotics: Overview01:23

Sedatives and Hypnotics: Overview

1.4K
Sedatives are drugs that alleviate anxiety, while hypnotics induce sleep. Both classes of medication suppress neuronal activity, leading to a calming effect for sedatives and facilitating sleep for hypnotics.
Sedative-hypnotics are categorized into barbiturates, benzodiazepines (BZDs), and non-benzodiazepines or Z-drugs. These drugs work by suppressing central nervous system activity, and this suppression is dose-dependent. Older sedative medications, like barbiturates, follow a linear curve in...
1.4K
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

656
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
656
Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

963
Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
963
Sedatives and Hypnotics Drugs: Benzodiazepines01:19

Sedatives and Hypnotics Drugs: Benzodiazepines

795
Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
795
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

533
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
533
General Anesthesia: Overview01:24

General Anesthesia: Overview

605
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
605

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical phenotyping of asthma patients with elevated sputum eosinophils and low blood eosinophils: a post-hoc analysis of the multicentre ATLANTIS cohort.

EBioMedicine·2026
Same author

Impact of Age on Treatment Response to Endobronchial Valve Treatment in Patients With Severe Emphysema.

Archivos de bronconeumologia·2026
Same author

Minimal Important Difference of FEV<sub>1</sub> and FVC in COPD Patients Undergoing Bronchoscopic Lung Volume Reduction.

Archivos de bronconeumologia·2026
Same author

Prospective clinical evaluation of the Eleveld pharmacokinetic and pharmacodynamic model of propofol for moderate-to-deep sedation in adults.

European journal of anaesthesiology·2026
Same author

Bronchial Thermoplasty Induced Changes in Blood Transcriptome Profile of Patients with Severe Asthma.

International journal of molecular sciences·2026
Same author

Bronchial thermoplasty for severe asthma: Systematic review and meta-analysis of benefits and harms.

The journal of allergy and clinical immunology. Global·2026

Related Experiment Video

Updated: Jan 20, 2026

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

12.8K

Collateral Ventilation Measurement Using Chartis: Procedural Sedation vs General Anesthesia.

Jorrit B A Welling1, Karin Klooster1, Jorine E Hartman1

  • 1Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands; Groningen Research Institute for Asthma and COPD, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Chest
|August 18, 2019
PubMed
Summary

Chartis measurements for severe emphysema treatment are faster and more feasible under general anesthesia compared to procedural sedation. This approach improves efficiency without compromising measurement outcomes for endobronchial valve therapy.

Keywords:
Chartis measurementcollateral ventilationendobronchial valve treatmentgeneral anesthesiaprocedural sedation

More Related Videos

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
04:46

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation

Published on: January 17, 2011

22.0K
High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster
06:15

High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster

Published on: April 20, 2020

7.5K

Related Experiment Videos

Last Updated: Jan 20, 2026

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia
06:50

Systematic Assessment of Well-Being in Mice for Procedures Using General Anesthesia

Published on: March 20, 2018

12.8K
A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation
04:46

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation

Published on: January 17, 2011

22.0K
High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster
06:15

High-Throughput Method for Measuring Alcohol Sedation Time of Individual Drosophila melanogaster

Published on: April 20, 2020

7.5K

Area of Science:

  • Pulmonary Medicine
  • Interventional Pulmonology
  • Respiratory Physiology

Background:

  • Endobronchial valve (EBV) treatment for severe emphysema relies on assessing interlobar collateral ventilation.
  • The Chartis measurement system is used to functionally assess collateral ventilation, validated under procedural sedation (PS) and general anesthesia (GA).
  • Performing Chartis measurements under PS presents challenges, including patient-reported discomfort and procedural difficulties.

Purpose of the Study:

  • To compare the outcomes of Chartis measurements performed under procedural sedation versus general anesthesia.
  • To evaluate differences in measurement duration, feasibility, and success rates between the two anesthesia methods.

Main Methods:

  • A prospective study involving 30 patients with severe emphysema.
  • Patients underwent Chartis measurements under both procedural sedation and general anesthesia.
  • Outcomes assessed included measurement duration, number of measurements, feasibility, and success rate.

Main Results:

  • Chartis measurement duration was significantly longer under PS (mean 20.3 min) than GA (mean 15.1 min).
  • Feasibility was significantly higher during GA (median score 7) compared to PS (median score 12).
  • Success rates were comparable (97% for GA vs. 77% for PS), though not statistically significant (P = .07).

Conclusions:

  • Chartis measurements for EBV treatment planning are more efficient and feasible under general anesthesia.
  • General anesthesia offers a more streamlined approach to assessing collateral ventilation compared to procedural sedation.
  • These findings support optimizing the procedural setting for improved patient management in severe emphysema.