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Updated: Jan 20, 2026

Author Spotlight: A Multi-Depth Porcine Model for Comprehensive Study of Burn Injuries and Healing Processes
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Indeterminate-Depth Burn Injury-Exploring the Uncertainty.

Aos S Karim1, Katherine Shaum1, Angela L F Gibson1

  • 1Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

The Journal of Surgical Research
|August 18, 2019
PubMed
Summary

Accurately determining burn depth is crucial for healing and regeneration. New imaging and wound healing technologies aim to improve management of indeterminate-depth burns (IDB), potentially avoiding skin grafts.

Keywords:
Burn depthDepth determinationIndeterminate-depth burnScarringSkin substitutes

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Area of Science:

  • Burn wound healing
  • Regenerative medicine
  • Medical imaging technologies

Background:

  • Indeterminate-depth burns (IDB) present significant management challenges, including predicting healing time and regenerative potential.
  • Current standard of care for burn depth determination relies heavily on visual assessment, despite existing technologies.
  • Burn wound progression and optimal timing for surgical excision remain critical concerns in IDB management.

Purpose of the Study:

  • To define indeterminate-depth burns (IDB) and outline associated clinical challenges.
  • To highlight the limitations of current diagnostic methods for burn depth.
  • To stimulate research into novel therapies and advanced management strategies for IDB.

Main Methods:

  • Review of existing literature on burn depth assessment and management.
  • Discussion of current and emerging imaging technologies for noninvasive burn depth determination.
  • Exploration of advancements in wound healing technologies.

Main Results:

  • Visual assessment remains the primary method for burn depth evaluation, despite its inherent inaccuracies.
  • Newer imaging technologies show promise for accurate, noninvasive, and cost-effective burn depth assessment.
  • Development of sophisticated wound healing technologies is enhancing IDB management.

Conclusions:

  • Improved diagnostic tools are needed to accurately assess burn depth and guide treatment.
  • Advancements in wound healing technologies offer potential for better outcomes in IDB.
  • The ultimate goal is to develop strategies for treating IDB without resorting to autografts.