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Updated: Jan 20, 2026

Expression, Purification, and Antimicrobial Activity of S100A12
Published on: May 13, 2017
The novel economical synthesis and antimicrobial activity of a trithiocarbonate derivative
Yahia N Mabkhot1, Jamal M A Khaled2, Mujeeb A S Sultan3
1Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Abstract:
The compound diethyl 2,2'-(thiocarbonyl-bis(sulfanediyl))-diacetate 4 belongs to the trithiocarbonate class containing a trithiocarbonate function group flanked by ethyl acetate. In this procedure, a novel economic synthesis route to obtain compound 4 is described. This compound proved to possess broad-spectrum antimicrobial activity both in vitro and in vivo, and could be used as a lead compound. It is worth mentioning that this compound has been patented [No. US 9,988,348 B1; date of patent: June 5, 2018].
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