Related Experiment Video

Updated: Jan 20, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.8K

MicroRNAs as Regulators and Biomarkers of Platelet Function and Activity in Coronary Artery Disease

Stefan Stojkovic1, Anne Yaël Nossent1, Paul Haller2

  • 1University Clinic for Internal Medicine II, Department of Cardiology, Medical University of Vienna, Vienna, Austria.

Thrombosis and Haemostasis
|August 18, 2019
PubMed

Insights

Platelet-related microribonucleic acids (miRs) regulate platelet activity and are implicated in coronary artery disease (CAD). These miRs show potential as biomarkers for diagnosing and managing CAD and acute coronary syndrome (ACS).

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Microribonucleic acids (miRs) are small, noncoding RNAs crucial for regulating biological processes.
  • Platelets play a significant role in cardiovascular health and disease, particularly in atherothrombosis.
  • Dysregulation of platelet function is a key factor in the development of coronary artery disease (CAD).

Purpose of the Study:

  • To review the role of platelet-related miRs in regulating platelet function and activity.
  • To summarize current research on platelet-related miRs as biomarkers in CAD and acute coronary syndrome (ACS).

Main Methods:

  • Literature review of recent studies.
  • Analysis of research investigating miRs in platelet biology.
  • Examination of studies on miRs as biomarkers in cardiovascular conditions.

Main Results:

  • Platelet-related miRs are integral to the mechanisms controlling platelet activation and function.
  • Emerging evidence suggests circulating miRs associated with platelets can serve as diagnostic and prognostic indicators.
  • These miRs are being explored for their utility in predicting treatment response in CAD and ACS patients.

Conclusions:

  • Platelet-related miRs are critical regulators of platelet function.
  • Circulating platelet-associated miRs hold promise as valuable biomarkers for CAD and ACS.
  • Further research is warranted to fully elucidate their clinical applications in cardiovascular medicine.

More Related Videos

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease04:41

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

Published on: July 3, 2018

8.6K
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease06:16

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease

Published on: August 9, 2024

816

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
903
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
380
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
218
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
332
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
596
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
24.0K