Related Experiment Video
Updated: Jan 20, 2026

Genetically-encoded Molecular Probes to Study G Protein-coupled Receptors
Published on: September 13, 2013
Molecular aspects of delta opioid receptors
Louis Gendron1, Karim Nagi2, Manel Zeghal3
1Department of Pharmacology-Physiology, Université de Sherbrooke, Centre de Recherche du CHUS, Sherbrooke, QC, Canada; Quebec Pain Research Network, Sherbrooke, QC, Canada.
Abstract:
The delta opioid receptor (DOP) belongs to the Class A, rhodopsin-like family of G protein-coupled receptors. Although this receptor has a high level of similarity with the other opioid receptors, it displays unique aspects and functions. Indeed, as opposed to most membrane receptors, DOP is poorly addressed to the plasma membrane. In this chapter, we first review the molecular and cellular mechanisms regulating the expression and the cellular trafficking/sorting of DOP. We then summarize the structural insights of this receptor through the analysis of the existing crystal structures, with a particular focus on the role of the sodium binding site. Finally, we review the current signaling mechanisms mediating receptor function and desensitization.
Related Concept Videos
Opioid Receptors: Overview
Quantitative Aspects of Drug-Receptor Interaction
The Delta-to-Delta Circuit
Opioid Analgesics: Synthetic and Semisynthetic Opioids
The Y-to-Delta Circuit
The initial step in analyzing a wye-to-delta circuit is to assume a positive phase sequence. These phase voltages are then utilized to calculate the line voltages that occur directly across the delta-connected load impedances. Van, Vbn, and Vcn are the phase voltages in wye, and Vab, Vbc, and Vca are the line voltages for a delta circuit. The relation between...
The Delta-to-Y Circuit

