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Vascular Detransformation for Cancer Therapy.
1Departments of Radiation Oncology and Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 19104, USA; Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Trends in Cancer
|August 19, 2019
Summary
Cancer vascularity may be driven by endothelial transformation, not just angiogenesis. Targeting this "vascular detransformation" could offer a new therapeutic strategy against cancer, overcoming current treatment limitations.
Area of Science:
- Oncology
- Cancer Biology
- Vascular Biology
Background:
- Angiogenesis is a critical hallmark of cancer.
- Current anti-vascular therapies targeting angiogenic factors show limited success in most cancers.
- Alternative mechanisms driving tumor vascularity require investigation.
Purpose of the Study:
- To propose endothelial transformation as a key driver of tumor vascularity.
- To explore endothelial transformation's role in cancer progression and immune suppression.
- To investigate endothelial transformation's contribution to therapeutic resistance.
Main Methods:
- Conceptual review of existing literature on angiogenesis and endothelial cell biology.
- Hypothesis generation based on observed limitations of current anti-angiogenic therapies.
- Proposed framework for understanding vascular abnormalities in cancer.
Main Results:
- Endothelial transformation is hypothesized to drive excessive and abnormal tumor vascularity.
- This transformation contributes to cancer progression and immune evasion.
- It also underlies resistance to existing cancer therapies.
Conclusions:
- Vascular detransformation, reversing endothelial transformation, presents a novel therapeutic strategy.
- This approach may overcome limitations of current anti-angiogenic treatments.
- Targeting vascular detransformation holds promise for improving cancer treatment outcomes.
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