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Rapid Analysis of Circadian Phenotypes in Arabidopsis Protoplasts Transfected with a Luminescent Clock Reporter
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Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment

Gabriele Sulli1, Michael Tun Yin Lam2, Satchidananda Panda3

  • 1The Salk Institute for Biological Studies, La Jolla, CA, USA; Department of Medicine, Division of Regenerative Medicine, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA; Scintillon Institute, San Diego, CA 92121, USA.

Trends in Cancer
|August 19, 2019
PubMed

Insights

Circadian clocks regulate body physiology and are crucial in cancer development. Modulating these clock genes offers a promising new avenue for cancer therapy and prevention.

Area of Science:

  • Chronobiology
  • Oncology
  • Molecular Biology

Background:

  • Circadian clocks are fundamental molecular mechanisms regulating physiological homeostasis.
  • Disrupted circadian rhythms are implicated in cancer initiation and progression, while cancer can also impair these rhythms.
  • The interplay between circadian biology and cancer is bidirectional.

Purpose of the Study:

  • To review the role of circadian clocks in tumorigenesis and cancer hallmarks.
  • To explore the potential of pharmacological modulation of core clock genes as a cancer therapy strategy.

Main Methods:

  • Literature review focusing on circadian biology and cancer research.
  • Analysis of studies investigating the link between circadian rhythm disruption and cancer hallmarks.
  • Examination of research on pharmacological interventions targeting circadian clock genes.

Main Results:

  • Circadian clock disruption is a significant factor in cancer development and progression.
  • Cancer processes can actively weaken the body's natural circadian rhythms.
  • Targeting core clock genes pharmacologically presents a novel therapeutic approach.

Conclusions:

  • Understanding circadian clock mechanisms is vital for cancer research.
  • Pharmacological modulation of circadian clock genes offers promising new strategies for cancer prevention, diagnosis, and treatment.
  • Integrating circadian biology into oncology can enhance treatment efficacy.
Keywords:
cancer hallmarkscancer therapycircadian clockcircadian rhythmstumorigenesis

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