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Effect of Low Dose Imipramine in Patients with Nocturnal Enuresis, A Randomized Clinical Trial

Yalda Ravanshad, Anoush Azarfar1, Mohammad Esmaeeli

  • 1Kidney Transplantation Complications Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. azarfara@mums.ac.ir.

Iranian Journal of Kidney Diseases
|August 19, 2019
PubMed

Insights

Combination therapy of desmopressin with low-dose imipramine effectively treats primary nocturnal enuresis in children unresponsive to desmopressin alone. This approach significantly improves recovery rates for bedwetting.

Area of Science:

  • Pediatrics
  • Urology
  • Pharmacology

Background:

  • Nocturnal enuresis significantly impacts children's quality of life.
  • Primary nocturnal enuresis often requires effective treatment strategies.
  • Desmopressin is a common treatment, but some patients do not respond adequately.

Purpose of the Study:

  • To evaluate the efficacy of combining low-dose imipramine with desmopressin for treating primary nocturnal enuresis.
  • To assess this combination therapy in children who are non-responders to desmopressin monotherapy.

Main Methods:

  • A randomized clinical trial involving 40 children (ages 5-12) with primary nocturnal enuresis.
  • Intervention group received desmopressin plus 5 mg imipramine; control group received desmopressin alone.
  • Patients were monitored weekly for one month, recording the number of wet nights.

Main Results:

  • The combination therapy group showed a significantly higher recovery rate (83.3%) compared to the desmopressin-only group (29.4%).
  • 18 out of 20 patients in the intervention group experienced improved enuresis after one month.
  • No significant differences in age or gender were observed between groups.

Conclusions:

  • Low-dose imipramine combined with desmopressin is a well-tolerated and effective short-term treatment for primary nocturnal enuresis.
  • This combination therapy offers a valuable option for desmopressin non-responders.
  • The findings support the use of combination therapy when monotherapy is insufficient.
Abstract

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