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Updated: Jan 20, 2026
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Intracortical Inhibition Within the Primary Motor Cortex Can Be Modulated by Changing the Focus of Attention
Published on: September 11, 2017
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Individual differences in intracortical inhibition predict motor-inhibitory performance
Jason L He1, I Fuelscher2, J Coxon3
1Cognitive Neuroscience Unit, School of Psychology, Deakin University, Burwood Campus, 221 Burwood Hwy, Burwood, VIC, Australia. jason.he@deakin.edu.au.
Experimental Brain Research
|August 19, 2019
Summary
Individual differences in resting short-interval intracortical inhibition (SICI) and long-interval intracortical inhibition (LICI) correlate with motor control. Greater SICI and LICI are linked to faster responses and improved inhibition on cognitive tasks.
Area of Science:
- Neuroscience
- Motor Control
- Cognitive Neuroscience
Background:
- Transcranial Magnetic Stimulation (TMS) measures neurophysiological biomarkers like SICI and LICI.
- Corticospinal excitability and intracortical inhibition change during action enactment and cancellation.
- The link between individual differences in these biomarkers and motor inhibition ability is unclear.
Purpose of the Study:
- To investigate the association between interindividual differences in SICI and LICI and motor inhibition performance.
- To determine if resting-state SICI and LICI predict performance on go/no-go and stop-signal tasks.
Main Methods:
- Paired-pulse TMS was used to measure SICI and LICI during motor tasks.
- Participants performed go/no-go and stop-signal tasks.
- Correlations between TMS measures and task performance metrics were analyzed.
Main Results:
- Individual differences in SICI and LICI were positively associated with performance metrics on the go/no-go and stop-signal tasks.
- Higher resting SICI and LICI correlated with faster responses on go trials.
- Greater SICI and LICI were linked to improved accuracy in inhibiting manual responses.
Conclusions:
- Resting-state SICI and LICI are associated with an individual's ability to restrain and cancel actions.
- These findings support a general relationship between GABAergic intracortical inhibitory functioning and motor inhibition.
- Individual differences in neurophysiological markers predict motor control capabilities.
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