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Carboxamide derivatives induce apoptosis in the U251 glioma cell line

Tao Yan1, Junxue Zhuang2, Lu He3

  • 1Department of Pharmacy, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China.

Oncology Letters
|August 20, 2019
PubMed

Insights

Two novel carboxamide derivatives show significant antitumor activity against glioma cells by inducing apoptosis and oxidative damage. These compounds inhibit proliferation and modulate key protein expressions, offering potential new treatments for malignant glioma.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Glioma is a prevalent malignant brain tumor often managed with chemotherapy.
  • Novel therapeutic agents are needed to improve glioma treatment outcomes.

Purpose of the Study:

  • To evaluate the antitumor efficacy of two novel carboxamide derivatives against glioma cells.
  • To elucidate the underlying mechanisms of their anticancer activity.

Main Methods:

  • Assessing proliferation, apoptosis, and oxidative stress in glioma U251 cells treated with carboxamide derivatives.
  • Measuring caspase-3, -8, and -9 activity.
  • Analyzing the expression levels of Bcl-2 and survivin proteins.

Main Results:

  • Carboxamide derivatives significantly inhibited glioma cell proliferation.
  • The compounds induced apoptosis and oxidative damage in U251 cells.
  • Increased caspase activity and suppressed Bcl-2/survivin expression were observed.

Conclusions:

  • The novel carboxamide derivatives exhibit potent in vitro antitumor activity against glioma.
  • Their mechanism involves the induction of oxidative damage and apoptosis.
  • These findings suggest potential therapeutic applications for glioma treatment.
Keywords:
apoptosiscarboxamide derivativesgliomaoxidative damage

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