Related Experiment Video
Updated: Jan 20, 2026
05:39
Spontaneous Murine Model of Anaplastic Thyroid Cancer
Published on: February 3, 2023
2.2K
Metabolic reprogramming and its clinical application in thyroid cancer
Shi-Shuai Wen1, Ting-Ting Zhang1, Di-Xin Xue2
1Department of Head and Neck Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, P.R. China.
Oncology Letters
|August 20, 2019
Summary
Metabolic reprogramming in thyroid cancer involves significant cellular changes beyond the Warburg effect. Understanding these metabolic alterations offers potential for improved diagnosis, prognosis, and targeted therapies for thyroid cancer.
Area of Science:
- Oncology
- Metabolic research
- Endocrinology
Background:
- The Warburg effect describes high glycolysis in tumor cells, even with oxygen.
- Metabolic reprogramming is now understood as a broader adaptation by cancer cells.
- Thyroid cancer, a common endocrine malignancy, exhibits unique metabolic characteristics.
Purpose of the Study:
- To review metabolic changes and mechanisms in thyroid cancer.
- To identify metabolic molecules for prognosis prediction and therapeutic targets.
- To explore the role of metabolic alterations in thyroid cancer diagnosis and treatment.
Main Methods:
- Literature review of metabolic alterations in thyroid cancer.
- Analysis of current research on metabolic pathways in thyroid cancer.
- Examination of potential therapeutic targets related to cancer metabolism.
Main Results:
- Metabolic reprogramming in thyroid cancer is complex and multifaceted.
- Several metabolic pathways and molecules are implicated in thyroid cancer progression.
- Drugs targeting tumor metabolism are currently in clinical trials for various cancers.
Conclusions:
- Metabolic alterations in thyroid cancer have significant implications for diagnosis and prognosis.
- Targeting metabolic pathways presents a promising therapeutic strategy for thyroid cancer.
- Further research is essential to validate these findings and develop clinical applications.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
3.3K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
3.3K
01:11Local Anesthetics: Clinical Application as Spinal Anesthesia
1.3K
Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
1.3K
01:29Local Anesthetics: Clinical Application as Epidural Anesthesia
692
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
692
00:52What is Metabolism?
131.2K
Overview
131.2K
01:23The Thyroid Gland
6.8K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.8K
01:16Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia
1.2K
Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...
One of the advantages of...
1.2K