Related Experiment Video

Updated: Jan 20, 2026

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

1.3K

Periprosthetic joint infection: current concepts and outlook

Petra Izakovicova1, Olivier Borens2, Andrej Trampuz3

  • 1HELIOS Klinik Zerbst/Anhalt, Germany.

EFORT Open Reviews
|August 20, 2019
PubMed

Insights

Periprosthetic joint infection (PJI) management is challenging due to biofilm persistence on implants. Improved diagnostics and biofilm-active antibiotics aid treatment, with antibiotic therapy limited to 12 weeks post-revision surgery.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Periprosthetic joint infection (PJI) is a severe complication of arthroplasty, affecting 1-2% of primary procedures.
  • Biofilm formation on implant surfaces presents a significant challenge in PJI treatment.
  • Understanding biofilm dynamics and host immune response is crucial for effective PJI management.

Purpose of the Study:

  • To review the challenges in managing periprosthetic joint infections (PJI).
  • To highlight the role of biofilm in PJI persistence and treatment.
  • To discuss advancements in diagnostic methods and antibiotic strategies for PJI.

Main Methods:

  • Review of current literature on PJI pathogenesis and management.
  • Analysis of diagnostic techniques, including sonication for biofilm detection.
  • Evaluation of biofilm-active antibiotics and treatment duration.

Main Results:

  • Biofilm formation on implants complicates PJI treatment.
  • Sonication enhances diagnostic sensitivity for PJI, particularly chronic cases.
  • Biofilm-active antibiotics are effective in eradicating microorganisms from implants.

Conclusions:

  • Effective PJI management requires understanding biofilm formation and antimicrobial susceptibility.
  • Advanced diagnostic tools like sonication improve PJI detection rates.
  • Targeted antibiotic therapy, limited to 12 weeks post-revision, is key for successful PJI treatment.
Keywords:
arthroplastybiofilmdiagnosisperiprosthetic joint infectiontreatment

More Related Videos

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice18:40

Combined In vivo Optical and µCT Imaging to Monitor Infection, Inflammation, and Bone Anatomy in an Orthopaedic Implant Infection in Mice

Published on: October 16, 2014

17.7K
Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs12:44

Creation of a Knee Joint-on-a-Chip for Modeling Joint Diseases and Testing Drugs

Published on: January 27, 2023

4.4K

Related Concept Videos

Self-Concept01:19

Self-Concept

Self-concept is the cognitive and emotional understanding individuals hold about their identity. It evolves through various developmental stages, beginning in infancy and maturing as children grow. This concept influences how individuals perceive their abilities, interact with others, and manage challenges throughout life.
Infancy and Emerging Recognition
During infancy, self-concept is virtually nonexistent. Babies do not distinguish themselves as separate entities and often mistake their...
1.5K
Structural Joints: Synovial Joints01:16

Structural Joints: Synovial Joints

Synovial joints are the most common type of joint in the body. A key structural characteristic for a synovial joint is the presence of a joint cavity. This fluid-filled space is where the articulating surfaces of the bones contact each other. Also, unlike fibrous or cartilaginous joints, the articulating bone surfaces at a synovial joint are not directly connected to each other with fibrous connective tissue or cartilage. This gives the bones of a synovial joint the ability to move smoothly...
6.4K
Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
3.6K
Structural Joints: Cartilaginous Joints01:17

Structural Joints: Cartilaginous Joints

As the name indicates, at a cartilaginous joint, the adjacent bones are united by cartilage, a tough but flexible type of connective tissue. Unlike synovial joints, these types of joints lack a joint cavity and involve bones joined together by either hyaline cartilage or fibrocartilage.
There are two types of cartilaginous joints:
Synchondrosis
A synchondrosis ("joined by cartilage") is a cartilaginous joint where bones are connected by hyaline cartilage. Synchondrosis may be temporary...
3.9K
Concepts and Prototypes01:24

Concepts and Prototypes

The human nervous system handles vast amounts of information by translating sensory stimuli into neural impulses, which the brain processes, creating thoughts expressed through language or stored as memories. The brain also synthesizes information from emotions and memories, which significantly influence thoughts and behaviors. This intricate process creates a comprehensive mental picture.
The brain organizes this information using concepts, which are mental categories grouping linguistic data,...
518
Joints01:26

Joints

Joints, also called articulations or articular surfaces, are points at which ligaments or other tissues connect adjacent bones. Joints permit movement and stability, and can be classified based on their structure or function.
Structural joint classifications are based on the material that makes up the joint as well as whether or not the joint contains a space between the bones. Joints are structurally classified as fibrous, cartilaginous, or synovial.
Fibrous Joints Are Immovable
The bones of a...
35.5K