Quantification of cutaneous allergic reactions using 3D optical imaging: A feasibility study

Area of Science:

• Dermatology
• Medical Imaging
• Biotechnology

Background:

• Quantitative assessment of cutaneous allergic reactions is crucial for effective management and treatment evaluation.
• Current methods lack user-independent measures for quantifying skin reactions, particularly to tattoos.

Purpose of the Study:

• To present and validate a novel method for quantifying the elevation, volume, and area of cutaneous allergic reactions to red tattoos.
• To establish user-independent, objective measurements for assessing tattoo-induced allergic responses.

Main Methods:

• Utilized an optical 3D scanner to image the skin surface of allergic tattoo reactions.
• Developed an analysis tool to measure lesion elevation, volume, and area against a reference surface created by 3D interpolation.
• Validated the interpolation and scanning methods using a digital arm model and a 3D printed lesion phantom, respectively.

Main Results:

• The 3D optical scanning method demonstrated potential for assessing skin elevation, volume change, and area of allergic reactions.
• Measurement error was influenced by interpolation area size; lesions ≥4 mm width and ≥0.4 mm elevation were measured with <26% error.
• Accurate measurements of lesions up to 600 mm² were achieved, enabling assessment of elevation and volume changes over time.

Conclusions:

• 3D optical scanning offers a feasible approach for quantifying cutaneous allergic reactions to red tattoos.
• This objective quantification method can enhance the management and evaluation of allergic reactions to tattoos.