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Updated: Jan 20, 2026
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Laboratory-determined Phosphorus Flux from Lake Sediments as a Measure of Internal Phosphorus Loading
Published on: March 6, 2014
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Multifunctional Nanoengineered Hydrogels Consisting of Black Phosphorus Nanosheets Upregulate Bone Formation
Zhenming Wang1,2, Jin Zhao1, Wanze Tang1
1Department of Spine Surgery and Institute for Orthopaedic Research, The 2nd Clinical Medical College (Shenzhen People's Hospital) of Jinan University, Shenzhen, 518020, China.
Small (Weinheim an Der Bergstrasse, Germany)
|August 20, 2019
Summary
Novel nanoengineered hydrogels incorporating black phosphorus (BP) nanosheets enhance bone regeneration. These advanced materials mimic the extracellular matrix (ECM), promoting osteogenic cell differentiation and mineralization for improved bone tissue repair.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Nanotechnology
Background:
- Tissue-engineered hydrogels are crucial for mimicking the extracellular matrix (ECM) due to their tunable properties.
- Developing advanced hydrogels that promote bone regeneration remains a significant challenge in regenerative medicine.
Purpose of the Study:
- To synthesize novel double network (DN) hydrogels with tunable mechanical properties.
- To construct nanoengineered (NE) hydrogels by incorporating black phosphorus (BP) nanosheets for enhanced ECM mimicry and bone regeneration.
Main Methods:
- Combinatorial screening methods were used to synthesize DN hydrogels.
- Ultrathin 2D black phosphorus (BP) nanosheets were added to DN hydrogels to create NE hydrogels.
- In vitro and in vivo studies were conducted to evaluate osteogenic differentiation and bone regeneration.
Main Results:
- The synthesized NE hydrogels exhibited tunable mechanical properties and enhanced mineralization ability due to BP nanosheets inducing CaP crystal formation.
- BP nanosheets and mineralized CaP crystal nanoparticles within the NE hydrogels created a favorable ECM microenvironment.
- Significant improvements in osteogenic cell differentiation and bone regeneration were observed in vitro and in vivo.
Conclusions:
- Nanoengineered hydrogels incorporating black phosphorus (BP) nanosheets show great potential for bone tissue regeneration.
- The combination of bioactive materials and mechanical stimuli in NE hydrogels offers a promising strategy for engineering bone regeneration.
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