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Related Experiment Video

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Curcumin for depression: a meta-analysis.

Laura Fusar-Poli1, Lucia Vozza1, Alberto Gabbiadini1

  • 1Department of Clinical and Experimental Medicine, Psychiatry Unit, University of Catania, Catania, Italy.

Critical Reviews in Food Science and Nutrition
|August 20, 2019
PubMed
Summary

Curcumin, derived from turmeric, shows promise in reducing depression and anxiety symptoms. This natural compound was well-tolerated and may complement standard treatments for major depressive disorder.

Keywords:
Curcuminanxietycurcumadepressionmeta-analysispsychiatryreviewturmeric

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Integrative Medicine

Background:

  • Curcumin, the active compound in turmeric (Curcuma longa), possesses anti-inflammatory and antioxidant properties.
  • These properties suggest potential therapeutic benefits for neuropsychiatric disorders, including depression.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of curcumin in treating depressive and anxiety symptoms.
  • To assess the safety and tolerability of curcumin in individuals with depression.

Main Methods:

  • A systematic review and meta-analysis were conducted following PRISMA guidelines.
  • Nine eligible studies involving 531 participants with major depressive disorder or secondary depression were included.
  • Data on depressive and anxiety symptom severity and curcumin's effects were analyzed.

Main Results:

  • Curcumin demonstrated a significant large effect size in reducing depressive symptoms (Hedge's g = -0.75) and anxiety symptoms (Hedge's g = -2.62).
  • Curcumin was generally well-tolerated by participants across the included studies.
  • The findings indicate a potential benefit of curcumin as an adjunct to standard care for depression.

Conclusions:

  • Curcumin supplementation may improve depressive and anxiety symptoms in individuals with depression.
  • While promising, results should be interpreted with caution due to small sample sizes.
  • Further research, especially in Western populations, is warranted to confirm these findings.