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Evaluation of Oxidative Stress in Biological Samples Using the Thiobarbituric Acid Reactive Substances Assay
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Evaluation of oxidative stress and antioxidant parameters in children with carbon monoxide poisoning

O Teksam1, S Sabuncuoğlu2, G Girgin2

  • 1Division of Pediatric Emergency Medicine, Department of Pediatrics, Faculty of Medicine, İhsan Doğramacı Children's Hospital, Hacettepe University, Ankara, Turkey.

Human & Experimental Toxicology
|August 20, 2019
PubMed

Insights

Carbon monoxide (CO) poisoning in children increases lipid peroxidation. However, neither normobaric oxygen (NBO) nor hyperbaric oxygen (HBO) therapy significantly impacts oxidative stress or antioxidant levels post-treatment.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Toxicology

Background:

  • Carbon monoxide (CO) poisoning is a significant health concern, particularly in children.
  • Oxidative stress plays a role in the pathophysiology of CO poisoning.
  • Understanding the impact of CO poisoning on oxidative stress and the efficacy of oxygen therapies is crucial.

Purpose of the Study:

  • To investigate oxidative stress and antioxidant parameter levels in pediatric patients diagnosed with CO poisoning.
  • To evaluate the effect of normobaric oxygen (NBO) and hyperbaric oxygen (HBO) treatments on these parameters.

Main Methods:

  • Prospective study in a pediatric emergency department (March 2015-April 2016).
  • Included 47 children with CO poisoning and 29 controls.
  • Measured oxidative stress and antioxidant markers in blood and urine before and after NBO or HBO treatment.

Main Results:

  • Children with CO poisoning exhibited significantly higher basal plasma malondialdehyde levels compared to controls (p=0.019).
  • NBO treatment showed a significant decrease in erythrocyte catalase enzyme levels (p=0.04) but no significant overall change in other oxidative stress markers.
  • HBO treatment did not result in significant changes in oxidative stress or antioxidant parameters before and after therapy.

Conclusions:

  • CO poisoning is linked to increased lipid peroxidation in children.
  • Current evidence suggests that neither NBO nor HBO therapy significantly alters oxidative stress or antioxidant parameters in pediatric CO poisoning patients.
  • Further research may be needed to explore alternative or adjunctive treatments.
Abstract

Keywords:
Carbon monoxideantioxidantschildrenoxidative stresspoisonings

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