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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Occurrence of acute myeloid leukemia in hydroxyurea-treated sickle cell disease patient

Samuel Regan1, Xuebin Yang2, Niklas K Finnberg3

  • 1Department of Medicine, College of Medicine, SUNY Upstate Medical University , Syracuse , New York , USA.

Cancer Biology & Therapy
|August 20, 2019
PubMed

Hydroxyurea (HU) has been widely used in sickle cell disease. Its potential long-term risk for carcinogenesis or leukemogenic risk remains undefined. Here, we report a 26 y old African-American female with Sickle Cell Disease (SCD) who developed refractory/relapsed acute myeloid leukemia (AML) 6 months after 26 months of HU use. That patient's cytogenetics and molecular genetics analyses demonstrated a complex mutation profile with 5q deletion, trisomy 8, and P53 deletion (deletion of 17p13.1). P53 gene sequence studies revealed a multitude of somatic mutations that most suggest a treatment-related etiology. The above-mentioned data indicates that the patient may have developed acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) as a direct result of HU exposure.

Keywords:
HydroxyureaP53 geneacute myeloid leukemia with myelodysplasia-related changessickle cell disease

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