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Updated: Jan 20, 2026

Scalable Syntheses of Graphene Oxide and Reduced Graphene Oxide using Cascade Design Oxidation and Highly Basic Reduction Reactions
Published on: July 3, 2025
Cycloaddition of Nitrile Oxides to Graphene: a Theoretical and Experimental Approach
Helena Uceta1, María Vizuete1, José R Carrillo2
1Instituto de Nanociencia, Nanotecnología y, Materiales Moleculares (INAMOL), Universidad de Castilla-La Mancha Campus de la Fábrica de Armas, 45071, Toledo, Spain.
Abstract:
Density functional theory (DFT) studies of the interaction between graphene sheets and nitrile oxides have proved the feasibility of the reaction through 1,3-dipolar cycloaddition. The viability of the approach has been also confirmed experimentally through the cycloaddition of few-layer exfoliated graphene and nitrile oxides containing functional organic groups with different electronic nature. The cycloaddition reaction has been successfully achieved in one-pot from the corresponding oximes under microwave (MW) irradiation. The successful formation of the isoxazoline ring has been confirmed by Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA) and X-ray photoelectron spectroscopy (XPS).
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