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Updated: Jan 20, 2026

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization
03:08

Using Human Differentially Expressed Gene Lists to Perform Downstream Pathway Enrichment Analysis and Target Prioritization

Published on: October 3, 2025

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Identification and Functional Enrichment Analysis of Potential Diagnostic and Therapeutic Targets in Adamantinomatous

Yang-Fan Zou1,2, Ling-Bing Meng3, Qing-Qing Wang4

  • 1Department of Neurosurgery, Affiliated Navy Clinical College of Anhui Medical University, Beijing, P.R. China.

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
|August 20, 2019
PubMed

Insights

Adamantinomatous craniopharyngioma (ACP) is a rare tumor. This study identified key genes and pathways, like RNA polymerase II promoter and glutamate receptor binding, involved in ACP development, offering potential new therapeutic targets.

Area of Science:

  • Neuro-oncology
  • Molecular Biology
  • Genomics

Background:

  • Adamantinomatous craniopharyngioma (ACP) is a congenital sellar region tumor with high recurrence rates after surgery.
  • Understanding ACP's molecular mechanisms is crucial for developing novel treatments.

Purpose of the Study:

  • To identify differentially expressed genes (DEGs) in ACP.
  • To explore the underlying molecular mechanisms and potential therapeutic targets for ACP.

Main Methods:

  • Analyzed gene expression profile GSE94349 from the Gene Expression Omnibus (GEO) database.
  • Identified DEGs using the limma package.
  • Performed Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, and constructed a protein-protein interaction (PPI) network.

Main Results:

  • Identified 109 DEGs (80 upregulated, 29 downregulated) in ACP compared to normal brain tissue.
  • Functional enrichment revealed involvement in RNA polymerase II promoter and glutamate receptor binding pathways.
  • Discovered 10 hub genes within the PPI network as potential therapeutic targets.

Conclusions:

  • DEGs play a significant role in ACP pathogenesis, particularly through RNA polymerase II promoter and glutamate receptor binding.
  • Identified hub genes represent promising targets for future ACP diagnosis and treatment strategies.
Keywords:
Gene OntologyKyoto Encyclopedia of Genes and Genomesadamantinomatous craniopharyngiomadifferentially expressed genesprotein–protein interaction

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