A comparison of the penetration of two quinolones into intra-abdominal abscess

Area of Science:

• Pharmacology
• Infectious Diseases
• Animal Models

Background:

• Intra-abdominal abscesses present treatment challenges.
• Understanding antibiotic penetration into abscesses is crucial for effective therapy.
• Quinolone antibiotics are commonly used for bacterial infections.

Purpose of the Study:

• To evaluate the penetration of ciprofloxacin and fleroxacin into pus within an intra-abdominal abscess model in rats.
• To compare the pharmacokinetic profiles of intravenous and oral administration of these agents in abscess cavities.

Main Methods:

• A low-mortality rat model of intra-abdominal abscess was utilized.
• Concentrations of ciprofloxacin and fleroxacin in pus and serum were measured over time after intravenous and oral administration.
• Pharmacokinetic parameters were analyzed.

Main Results:

• Maximum pus concentrations for intravenous ciprofloxacin and fleroxacin were achieved at 4 hours.
• Oral fleroxacin reached maximum pus levels at 2 hours.
• Fleroxacin demonstrated higher concentrations in pus than serum up to 8 hours; ciprofloxacin exceeded serum levels after 1.5 hours.

Conclusions:

• Ciprofloxacin and fleroxacin exhibit significant penetration into established intra-abdominal abscesses.
• These quinolones possess unique properties for abscess penetration.
• They may play a vital therapeutic role in treating patients with complex abscesses, such as multiple interloop abscesses.