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Substantiating Appropriate Motion Capture Techniques for the Assessment of Nordic Walking Gait and Posture in Older Adults
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Nordic OCD & Related Disorders Consortium: Rationale, design, and methods
David Mataix-Cols1,2, Bjarne Hansen3,4, Manuel Mattheisen5,6,7,8
1Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Summary
This study establishes the Nordic OCD and Related Disorders Consortium (NORDiC) to investigate the genetic and environmental causes of obsessive-compulsive disorder (OCD). The initiative aims to identify biological targets for improved treatment outcomes.
Area of Science:
- Psychiatry
- Genetics
- Epidemiology
Background:
- Obsessive-compulsive disorder (OCD) is a severe psychiatric condition with unknown etiology.
- Current genetic findings for OCD are limited, hindering the identification of biological targets for improved treatments.
- Understanding OCD's causal mechanisms is crucial for reducing patient morbidity and societal costs.
Purpose of the Study:
- To establish the Nordic OCD and Related Disorders Consortium (NORDiC) for a large-scale, etiologically informative genetic study of OCD.
- To integrate genetic and environmental factors implicated in the development of OCD.
- To answer key questions regarding the biology, etiology, and treatment of OCD.
Main Methods:
- Formation of the Nordic OCD and Related Disorders Consortium (NORDiC).
- Collection of a large, richly phenotyped, and genotyped sample of OCD cases from Nordic countries.
- Leveraging detailed population registers, national healthcare systems, and specialist OCD clinics.
- Detailed clinical measures and planned genomic analyses.
Main Results:
- The establishment and methodology of the NORDiC consortium are described.
- A large-scale, phenotyped, and genotyped sample of OCD cases is being collected.
- The study is designed to integrate genetic and environmental factors for etiological insights.
Conclusions:
- The NORDiC consortium provides a robust framework for advancing OCD research.
- This initiative is expected to yield significant insights into the genetic and environmental underpinnings of OCD.
- Improved understanding will facilitate the identification of novel biological targets and enhance treatment strategies for OCD.
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