Related Experiment Video
Updated: Jan 20, 2026
07:00
A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
10.4K
Association between H19 polymorphisms and NSCLC risk in a Chinese Population
Guangzheng Wang1, Qun Liu, Kai Cui
1Department of Pharmacy, Liaocheng Infectious Disease Hospital, Liaocheng, China.
Summary
H19 gene polymorphisms, specifically rs2067051 and rs217727, may influence non-small cell lung cancer (NSCLC) risk in the Chinese population. Further research is needed to understand these genetic associations.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Long non-coding RNAs (lncRNAs) play roles in cancer development.
- H19 is a lncRNA implicated in various cancers.
- Genetic variations in lncRNAs, like H19, may affect cancer risk.
Purpose of the Study:
- To investigate the association between H19 gene polymorphisms and non-small cell lung cancer (NSCLC) susceptibility.
- To evaluate the impact of specific H19 single nucleotide polymorphisms (SNPs) on NSCLC risk in a Chinese population.
Main Methods:
- A case-control study was conducted.
- Genotyping of four H19 SNPs (rs2067051, rs217727, rs2839698, rs4929984) was performed.
- The study included 564 NSCLC cases and 1536 controls from a Chinese population.
Main Results:
- The H19 SNP rs2067051 was associated with a decreased risk of NSCLC.
- The H19 SNP rs217727 was linked to an increased susceptibility to NSCLC.
- No significant association was found between H19 SNPs rs2839698, rs4929984 and NSCLC risk.
Conclusions:
- H19 polymorphisms rs2067051 and rs217727 may modulate NSCLC susceptibility.
- The underlying mechanisms require further investigation.
Related Concept Videos
02:04Conservation of Small Populations
16.7K
Small population sizes put a species at extreme risk of extinction due to a lack of variation, and a consequent decrease in adaptability. This weakens the chances of survival under pressures such as climate change, competition from other species, or new diseases. Large populations are more likely to survive pressures such as these, as such populations are more likely to harbor individuals that have genetic variants that are adaptive under new stresses. Small populations are much less...
16.7K
01:25What is Population Genetics?
64.5K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.5K
00:57Population Growth
27.9K
Population size is dynamic, increasing with birth rates and immigration, and decreasing with death rates and emigration. In ideal conditions with unlimited resources, populations can increase exponentially, which plots as a J-shaped growth rate curve of population size against time. This type of curve is characteristic of newly-introduced invasive species, or populations that have suffered catastrophic declines and are rebounding.
27.9K
01:12Relative Risk
2.0K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.0K
01:05Single Nucleotide Polymorphisms-SNPs
18.0K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.0K
01:21Association Areas of the Cortex
9.0K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
9.0K