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Updated: Jan 20, 2026

Orthotopic Mouse Model of Colorectal Cancer
Published on: December 4, 2007
Significant association between MDM2 T309G polymorphism and colorectal cancer
Mustafa Atabey1, Ayca Tas, Ismail Sari
1Clinic of General Surgery, Medicana Sivas Hospital, Sivas, Turkey.
Purpose:
The Murine double minute 2 (MDM2) gene plays a crucial role in regulating and suppressing the function of apoptotic pathway. We investigated the relationship between MDM2 gene SNP309 (T309G) (rs2279744) polymorphism and colorectal cancer (CRC) in a Turkish population.
Methods:
The polymorphism T309G (rs2279744) in the MDM2 gene was studied in patients with colorectal cancer (n=135) and healthy control subjects (n=145) using the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method. The findings were evaluated using logistic regression and x2 tests.
Results:
When CRC cases and controls were evaluated based on different habits and family cancer histories, a statistically significant relationship was found between CRC and alcohol consumption (x2=4.07, p=0.044). Cancer cases and controls had statistically significant different family histories of cancer (x2=6.82, p=0.009). There was also significant difference in TG genotype distribution in the MDM2 T309G polymorphism between those with and without cancer (OR=1.98, 95% CI=1.98-3.91, x2=4.00, p=0.045).
Conclusions:
The SNP309 polymorphism of the MDM2 gene is associated with increased CRC risk in the Turkish population.
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