Related Experiment Video

Updated: Jan 20, 2026

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
14:35

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Published on: April 17, 2021

9.0K

Blood Leukocyte DNA Methylation Predicts Risk of Future Myocardial Infarction and Coronary Heart Disease

Golareh Agha1, Michael M Mendelson2,3,4, Cavin K Ward-Caviness5,6

  • 1Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York (G.A., A.A.B.).

Circulation
|August 20, 2019
PubMed

Insights

DNA methylation in blood is linked to future coronary heart disease (CHD) risk. These findings, from large prospective studies, may help predict and understand CHD development.

Area of Science:

  • Epigenetics
  • Cardiovascular Disease Epidemiology

Background:

  • DNA methylation is associated with coronary heart disease (CHD).
  • Previous evidence was limited by small, cross-sectional studies.
  • This study investigates blood DNA methylation in relation to incident CHD in large prospective cohorts.

Purpose of the Study:

  • To examine the association between blood DNA methylation patterns and the risk of developing incident coronary heart disease (CHD).
  • To identify specific DNA methylation sites (CpGs) associated with future CHD events.
  • To explore the potential causal role of DNA methylation in CHD development.

Main Methods:

  • Epigenome-wide DNA methylation profiling using Illumina Infinium 450k microarray across nine population-based cohorts.
  • Prospective ascertainment of CHD events (myocardial infarction, revascularization, coronary death).
  • Meta-analysis of race-specific Cox proportional hazards models, adjusting for relevant covariates and cell type proportions.

Main Results:

  • 52 CpG sites in blood DNA methylation were significantly associated with incident CHD or myocardial infarction.
  • Associated CpGs map to genes involved in calcium regulation, kidney function, and previously identified CHD risk factors.
  • Mendelian randomization analyses supported a causal role for DNA methylation in incident CHD.

Conclusions:

  • Blood DNA methylation is associated with future coronary heart disease (CHD) risk across diverse populations.
  • DNA methylation may serve as a valuable biomarker for CHD risk prediction.
  • Further research into methylation patterns can enhance understanding of CHD pathogenesis.
Abstract

Keywords:
coronary artery diseasecoronary heart diseaseepigeneticsgene expression regulationgenomics

More Related Videos

Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.6K
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

5.2K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
903
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
380
Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
218
Anatomy of the Heart01:27

Anatomy of the Heart

The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
119.4K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
454
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
332