Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Per-Unit Sequence Models01:26

Per-Unit Sequence Models

432
An ideal Y-Y transformer, grounded through neutral impedances, displays per-unit sequence networks akin to those of a single-phase ideal transformer when subjected to balanced positive- or negative-sequence currents. These currents do not produce neutral currents, and their associated voltage drops.
Zero-sequence currents, which are identical in magnitude and phase, generate a neutral current, resulting in voltage drops across the neutral impedance and the low-voltage winding. If the...
432
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

11.6K
Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
11.6K
Cis-regulatory Sequences02:02

Cis-regulatory Sequences

4.0K
4.0K
Sanger Sequencing01:57

Sanger Sequencing

773.4K
DNA sequencing is a fundamental technique that is routinely used in the biological sciences. This method can be applied to a range of questions at different scales - from the sequencing of a cloned DNA fragment or the study of a mutation in a gene up to whole-genome sequencing. However, despite the widespread use of sequencing today, it was not until 1977 that Fredrick Sanger and his collaborators developed the chain-termination method to decode DNA sequences. It relies on the separation of a...
773.4K
Next-generation Sequencing03:00

Next-generation Sequencing

97.9K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
97.9K
Maxam-Gilbert Sequencing01:05

Maxam-Gilbert Sequencing

12.7K
In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
Challenges of the Maxam-Gilbert Method
The...
12.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The plasma metabolome and clinical features of patients with coeliac disease in Northwest China.

Annals of medicine·2026
Same author

Integrative computational elucidation of molecular mechanisms and multi-target interactions in paraquat-induced pulmonary fibrosis.

Toxicology and industrial health·2026
Same author

Microplastic exposure and human health risks across the life cycle: a focus on reproduction, development, and aging.

Frontiers in cell and developmental biology·2026
Same author

Biological processes dominate the dynamic changes in the dissolved inorganic carbon ion equilibrium system of coastal wetlands under tidal influence.

Marine environmental research·2026
Same author

The Incidence and Risk Factors of Antibiotic-Associated Diarrhea in Critically Ill Patients: A Systematic Review and Meta-Analysis.

Journal of gastroenterology and hepatology·2026
Same author

Discovery and functional characterization of endoglucanases from <i>Coptotermes formosanus</i> with enhanced cellulose hydrolysis via yeast surface display.

Applied and environmental microbiology·2026
Same journal

Granular Ball-Based Noise-Resistant Fuzzy Multineighborhood Feature Selection via Label Enhancement and Feature Graph.

IEEE transactions on neural networks and learning systems·2026
Same journal

Fighting Evolving Spam With ARTMAP Models: A Noise-Resilient Online Detection Framework.

IEEE transactions on neural networks and learning systems·2026
Same journal

HyperSAT: Unsupervised Hypergraph Neural Networks for Weighted MaxSAT Problems.

IEEE transactions on neural networks and learning systems·2026
Same journal

Negation of Basic Belief Assignment in Multisource Information Fusion on Dempster-Shafer Theory With Applications in Pattern Classification.

IEEE transactions on neural networks and learning systems·2026
Same journal

Intervention Feasible Region and Driver Risk Capacity Aware Human-Machine Collaborative Safe Trajectory Planning.

IEEE transactions on neural networks and learning systems·2026
Same journal

A Unified Differential Denoising Learning Framework With a Pre-Trained Model and Fuzzy Graph Networks for Drug-Drug Interaction Prediction.

IEEE transactions on neural networks and learning systems·2026
See all related articles

Related Experiment Video

Updated: Jan 20, 2026

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
09:34

A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

Published on: September 25, 2021

4.5K

Deep Reinforcement Learning for Sequence-to-Sequence Models.

Yaser Keneshloo, Tian Shi, Naren Ramakrishnan

    IEEE Transactions on Neural Networks and Learning Systems
    |August 20, 2019
    PubMed
    Summary
    This summary is machine-generated.

    This survey explores using reinforcement learning (RL) to improve sequence-to-sequence (seq2seq) models. RL addresses common issues like exposure bias and train/test inconsistencies in tasks such as text summarization.

    More Related Videos

    Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
    09:36

    Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

    Published on: July 2, 2016

    17.6K
    Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples
    07:30

    Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples

    Published on: June 8, 2020

    12.7K

    Related Experiment Videos

    Last Updated: Jan 20, 2026

    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data
    09:34

    A Virtual Machine Platform for Non-Computer Professionals for Using Deep Learning to Classify Biological Sequences of Metagenomic Data

    Published on: September 25, 2021

    4.5K
    Unbiased Deep Sequencing of RNA Viruses from Clinical Samples
    09:36

    Unbiased Deep Sequencing of RNA Viruses from Clinical Samples

    Published on: July 2, 2016

    17.6K
    Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples
    07:30

    Optimization for Sequencing and Analysis of Degraded FFPE-RNA Samples

    Published on: June 8, 2020

    12.7K

    Area of Science:

    • Artificial Intelligence
    • Natural Language Processing
    • Machine Learning

    Background:

    • Sequence-to-sequence (seq2seq) models, based on deep neural networks, excel in tasks like machine translation and text summarization.
    • Current seq2seq models face challenges including exposure bias and inconsistencies between training and testing metrics.
    • Existing improvements like attention and pointer-generation models have limitations.

    Purpose of the Study:

    • To investigate the application of reinforcement learning (RL) to address inherent problems in seq2seq models.
    • To present a novel formulation combining RL's decision-making capabilities with seq2seq architectures for enhanced memory.
    • To offer insights into current challenges and propose solutions using advanced RL models.

    Main Methods:

    • A survey of recent frameworks integrating RL and deep neural networks for seq2seq tasks.
    • Formulation of seq2seq problems from a reinforcement learning perspective.
    • Implementation of RL models for abstractive text summarization, including source code provision.

    Main Results:

    • Demonstration of RL's potential to mitigate exposure bias and improve train/test consistency in seq2seq models.
    • Experimental validation of RL-based models for abstractive text summarization.
    • Analysis of performance and training time for proposed RL models.

    Conclusions:

    • Reinforcement learning offers a promising approach to overcome limitations in current seq2seq models.
    • The integration of RL with deep learning enhances model decision-making and long-term memory.
    • Further research into advanced RL models can lead to more robust and efficient seq2seq systems.