Grade 3 Echocardiographic Diastolic Dysfunction Is Associated With Increased Risk of Major Adverse Cardiovascular...

Area of Science:

• Cardiology
• Cardiovascular Surgery
• Echocardiography

Background:

• Diastolic dysfunction is a prevalent condition associated with increased cardiovascular risk.
• Isolated left ventricular diastolic dysfunction poses a significant threat for cardiovascular complications.

Purpose of the Study:

• To investigate the association between the grade of diastolic dysfunction and major adverse cardiovascular events (MACEs) in patients with isolated diastolic dysfunction undergoing noncardiac surgery.
• To determine if higher grades of diastolic dysfunction correlate with increased MACE risk post-surgery.

Main Methods:

• Retrospective cohort study including adult patients with isolated echocardiographic diastolic dysfunction (ejection fraction ≥50%).
• Data collected for patients undergoing noncardiac surgery between January 1, 2015, and December 31, 2015.
• Multivariable logistic regression analysis used to assess the association between diastolic dysfunction grade and postoperative MACEs.

Main Results:

• A total of 2976 patients were analyzed, with 10.0% experiencing MACEs post-surgery.
• Grade 3 diastolic dysfunction was significantly associated with a higher risk of postoperative MACEs (OR, 1.71; 95% CI, 1.28-2.27; P < .001) compared to grades 1 and 2.
• Patients with grade 3 diastolic dysfunction also had more non-MACE complications (OR, 1.44; 95% CI, 1.07-1.95; P = .017).

Conclusions:

• In patients with isolated diastolic dysfunction undergoing noncardiac surgery, 10.0% experienced MACEs during hospital stay.
• Grade 3 diastolic dysfunction is a significant predictor of increased MACE risk following noncardiac surgery.