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Updated: Jan 20, 2026
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Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
Published on: October 25, 2019
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Leptin and adiponectin dynamics at patients with rectal neoplasm - Gender differences
Alexandru Florescu1, Dumitru Branisteanu1, Stefana Bilha1
1Department of Endocrinology, "Grigore T. Popa" University of Medicine and Pharmacy, Iasi, Romania.
Plos One
|August 20, 2019
Summary
Rectal carcinoma (RC) patients show altered adipokine levels compared to healthy individuals, with significant changes post-surgery. Gender differences in adipokine profiles and their correlation with body weight were observed in RC patients.
Area of Science:
- Endocrinology
- Oncology
- Metabolic Research
Background:
- Adipokines are linked to colorectal cancer, but specific data for rectal carcinoma (RC) are limited.
- Understanding adipokine profiles in RC patients is crucial for disease management.
Purpose of the Study:
- To compare leptin and adiponectin levels in rectal carcinoma patients versus healthy controls.
- To investigate the changes in adipokine levels following surgical intervention in RC patients.
Main Methods:
- Serum leptin and adiponectin were measured in 59 RC patients before and at several time points after surgery.
- A control group of age- and weight-matched healthy individuals was included for comparison.
- Correlations with body weight, gender, and surgical factors were analyzed.
Main Results:
- RC patients exhibited different adipokine levels than controls, with variations based on gender.
- Surgery induced significant, temporary alterations in leptin and adiponectin levels.
- Adipokine levels correlated with body weight, with gender-specific differences in this association post-surgery.
Conclusions:
- Adipokine levels in RC patients differ from healthy individuals, potentially indicating disease adaptation.
- Post-surgical adipokine fluctuations are likely due to surgical stress.
- Observed gender differences in adipokine profiles suggest potential clinical relevance for rectal carcinoma management.
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