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Related Experiment Videos

Risk factors for persistent diarrhoea.

N S Shahid1, D A Sack, M Rahman

  • 1International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh.

BMJ (Clinical Research Ed.)
|October 22, 1988
PubMed
Summary
This summary is machine-generated.

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Persistent diarrhea in young children is linked to factors like bloody stools, respiratory infections, malnutrition, and vitamin A deficiency. These risk factors increase mortality in children under five.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Persistent diarrhea is a significant health concern in children under five.
  • Identifying risk factors is crucial for effective intervention and reducing mortality.

Purpose of the Study:

  • To conduct a retrospective analysis of persistent diarrhea in children under five.
  • To identify risk factors associated with persistent diarrhea.

Main Methods:

  • Systematic sampling of children under five with diarrheal disease.
  • Retrospective analysis comparing children with persistent diarrhea ( > 14 days) to those with acute diarrhea.
  • Matched case-control study design.

Main Results:

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  • 10% of 4155 children had persistent diarrhea.
  • Strongly associated risk factors included bloody/mucus stools, lower respiratory tract infection, malnutrition, vitamin A deficiency, and prior antibiotic use.
  • Peak incidence at 2 years; no sex difference. Higher mortality in persistent diarrhea cases.
  • No significant association with Shigella, Campylobacter jejuni, or Giardia lamblia isolation rates.

    • Conclusions:

    • Several key factors significantly increase the risk of persistent diarrhea in young children.
    • Early identification and management of these risk factors are essential for improving outcomes and reducing child mortality.
    • Further research may be needed to clarify the role of diet and specific pathogens.