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Gastroschisis: State of the Art in Translating Experimental Research to the Bedside
Lourenço Sbragia1, Rebeca Lopes Figueira1, Karina Miura da Costa1
1Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Insights
Gastroschisis (GS) survival is up, but high morbidity persists due to intestinal issues. Experimental models have advanced understanding and potential treatments for this congenital defect.
Area of Science:
- Neonatal surgery
- Developmental biology
- Gastroenterology
Background:
- Gastroschisis (GS) is a congenital defect with increasing survival rates but persistent high morbidity.
- Morbidity is primarily linked to prolonged hospitalization, impaired intestinal motility, malabsorption, and infection risk.
Purpose of the Study:
- To review key experimental models of gastroschisis.
- To describe the translational and historical impact of research on understanding and managing GS.
Main Methods:
- Review of experimental models used in gastroschisis research.
- Analysis of research advancements in pathophysiology, embryology, and therapeutic strategies.
Main Results:
- Experimental models have significantly improved understanding of GS pathophysiology.
- Research has explored gene targets, amniotic fluid influence, and potential fetal therapies.
- These advances aim to reduce intestinal damage and accelerate motility recovery.
Conclusions:
- Experimental models are crucial for advancing gastroschisis research.
- Translational research offers hope for reducing GS-related morbidity and improving outcomes.
Abstract:
The survival rate of newborns with gastroschisis (GS) has been increasing in the past decades; however, the morbidity continues to be high, mainly related to the length of hospitalization due to disturbances of motility, absorption, and risk of intestinal infections. The development of basic research with the creation of experimental models has provided enormous advances in the understanding of the pathophysiology of the disease. These models allowed the study of the target genes involved in the embryology of the defect, the influence of the amniotic fluid, and the use of drugs and fetal therapies in an attempt to reduce the intestinal damage and to provide a rapid return of intestinal motility. Our aim was to describe the main GS models and the translational, historical impact of these research advances on the disease.
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