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Updated: Jan 20, 2026

Production and Detection of Reactive Oxygen Species ROS in Cancers
Published on: November 21, 2011
Reactive Oxygen Species in the Tumor Microenvironment: An Overview
Frank Weinberg1, Nithya Ramnath1,2, Deepak Nagrath3,4,5
1Division of Hematology and Oncology, Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
Reactive oxygen species (ROS) are important signaling molecules in cancer. The level of ROS will determine physiological effects. While high levels of ROS can cause damage to tissues and cell death, low levels of ROS can have a proliferative effect. ROS are produced by tumor cells but also cellular components that make up the tumor microenvironment (TME). In this review, we discuss the mechanisms by which ROS can affect the TME with particular emphasis on tumor-infiltrating leukocytes. Greater insight into ROS biology in this setting may allow for therapeutic manipulation of ROS levels in order to remodel the tumor microenvironment and increase anti-tumor activity.
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