Related Experiment Video
Updated: Jan 20, 2026

Measuring Neuromuscular Junction Functionality
Published on: August 6, 2017
Neuromuscular Junction as an Entity of Nerve-Muscle Communication
Elisa Lepore1, Irene Casola1, Gabriella Dobrowolny1
1Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, DAHFMO-Unit of Histology and Medical Embryology, Sapienza University of Rome, Via A. Scarpa, 14, 00161 Rome, Italy.
Abstract:
One of the crucial systems severely affected in several neuromuscular diseases is the loss of effective connection between muscle and nerve, leading to a pathological non-communication between the two tissues. The neuromuscular junction (NMJ) represents the critical region at the level of which muscle and nerve communicate. Defects in signal transmission between terminal nerve endings and muscle membrane is a common feature of several physio-pathologic conditions including aging and Amyotrophic Lateral Sclerosis (ALS). Nevertheless, controversy exists on whether pathological events beginning at the NMJ precede or follow loss of motor units. In this review, the role of NMJ in the physio-pathologic interplay between muscle and nerve is discussed.
More Related Videos
Related Concept Videos
The Neuromuscular Junction
Neuromuscular Junction And Blockade
Communication
Communication
P-N junction
Therapeutic Communication
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...

