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Targeting Oncogenic BRAF: Past, Present, and Future

Aubhishek Zaman1,2, Wei Wu1,2, Trever G Bivona3,4

  • 1Department of Medicine, University of California, San Francisco, CA 94143, USA.

Cancers
|August 21, 2019
PubMed

Insights

Targeted BRAF kinase inhibitors treat BRAF-driven cancers, but resistance develops. This review explores BRAF mutations, resistance mechanisms, and strategies to overcome them for improved cancer therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • BRAF alterations drive specific cancers, leading to precision medicine approaches.
  • Targeted BRAF inhibitors are effective but face inevitable therapeutic resistance.

Purpose of the Study:

  • To review BRAF biology in both normal and mutated states.
  • To outline current and emerging therapeutic strategies for BRAF-driven tumors.
  • To discuss mechanisms of resistance to BRAF-targeted therapies.

Main Methods:

  • Literature review of BRAF biology and targeted therapies.
  • Analysis of resistance mechanisms in BRAF-mutant cancers.
  • Exploration of novel therapeutic strategies.

Main Results:

  • Predominant BRAF mutations and their role in cancer identified.
  • Common resistance mechanisms, including tumor heterogeneity, are highlighted.
  • Promising therapeutic approaches to overcome resistance are discussed.

Conclusions:

  • Understanding BRAF biology and resistance is crucial for effective cancer treatment.
  • Developing strategies to overcome resistance can improve long-term control of BRAF-driven tumors.
  • Integrated knowledge can lead to more preemptive and effective therapeutic interventions.
Keywords:
BRAFdrug resistanceoncogeneprecision medicinetargeted therapy

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