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Recent Advances in Pharmacological and Non-Pharmacological Strategies of Cardioprotection

Afonso Caricati-Neto1, Paolo Ruggero Errante2, Francisco Sandro Menezes-Rodrigues2

  • 1Department of Pharmacology, Laboratory of Autonomic and Cardiovascular Pharmacology, Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), Vila Clementino, São Paulo-SP 04039-032, Brazil. caricatineto@gmail.com.

International Journal of Molecular Sciences
|August 21, 2019
PubMed

Insights

Ischemic heart disease treatment involves reperfusion, which can paradoxically harm the heart. Cardioprotection strategies, both drug-based and non-drug-based, offer ways to shield the heart from this damage.

Area of Science:

  • Cardiology
  • Molecular Biology
  • Pharmacology

Background:

  • Ischemic heart diseases (IHD) are a leading global cause of mortality.
  • Myocardial reperfusion, a primary IHD treatment, can induce severe cardiac dysfunction due to oxygen reperfusion injury and ionic imbalance.
  • Cardioprotection refers to cellular defense mechanisms against ischemia-reperfusion (I/R) injury.

Purpose of the Study:

  • To review recent advancements in pharmacological and non-pharmacological cardioprotection strategies.
  • To highlight the importance of understanding cellular and molecular mechanisms in IHD treatment.

Main Methods:

  • Analysis of recent scientific literature on cardioprotection.
  • Examination of intracellular signaling pathways and organelles involved in protective responses.
  • Review of pharmacological agents and non-pharmacological procedures for cardioprotection.

Main Results:

  • Cardioprotective responses involve complex intracellular signaling pathways.
  • Pharmacological agents (e.g., adenosine) and non-pharmacological methods (e.g., conditioning) can stimulate cardioprotection.
  • Understanding these mechanisms is key to developing novel therapeutic strategies.

Conclusions:

  • Advancing the understanding of cardioprotection mechanisms is crucial for improving IHD treatment efficacy.
  • New pharmacological and non-pharmacological strategies hold promise for mitigating reperfusion injury.
  • Targeting cellular defense mechanisms can enhance outcomes for patients with ischemic heart disease.

Keywords:
cardiac ischemia and reperfusioncardioprotectioncardioprotective drugsischemic conditioning

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