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Updated: Oct 23, 2026
08:58
Matrix-assisted Autologous Chondrocyte Transplantation for Remodeling and Repair of Chondral Defects in a Rabbit Model
Published on: May 21, 2013
[Nucleolytic action of chondroitinase ABC on the lumbar disc of the rabbit]
N Henderson1, V Stanescu, J Cauchoix
1Institut de Recherche sur les Maladies du Squelette, Berck-sur-Mer.
Abstract:
Nucleolysis using chondroitinase ABC was studied using the rabbit's intervertebral lumbar disc. The purpose was to find a possible alternative to chymopapain which is commonly used in the management of sciatica due to disc herniation. The injection of 1 U of the enzyme into the nucleus pulposus gave significant histological and biochemical changes in all twelve discs studied.
