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Selenium-containing polysaccharides from Lentinula edodes-Biological activity.

Beata Kaleta1, Andrzej Górski2, Radosław Zagożdżon3

  • 1Department of Clinical Immunology, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warsaw, Poland.

Carbohydrate Polymers
|August 21, 2019
PubMed
Summary

Selenium-enriched polysaccharides demonstrated enhanced biological activity, selectively suppressing T lymphocyte proliferation while boosting normal and malignant cell viability. This suggests selenium enhances polysaccharide therapeutic potential.

Keywords:
ImmunosuppressantsLentinula edodesLymphocytes TSe-polysaccharidesSelenium

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Area of Science:

  • Biotechnology
  • Immunology
  • Pharmacology

Background:

  • Mushroom-derived polysaccharides, like lentinan, are known for biological activities.
  • The role of selenium enrichment in modulating polysaccharide bioactivity is underexplored.

Purpose of the Study:

  • To investigate if selenium (Se)-enriched polysaccharides exhibit superior biological activity compared to non-enriched counterparts.
  • To evaluate the effects of Se-enriched and non-enriched lentinan analogs on human immune cells and cell viability.

Main Methods:

  • Biotechnological production of Se-enriched and non-enriched lentinan fractions.
  • Assessment of T and B lymphocyte proliferation inhibition using mitogen stimulation.
  • Evaluation of cell viability and oxidative stress protection in normal (HUVEC) and malignant (HeLa) cells.

Main Results:

  • Both Se-enriched and non-enriched fractions selectively inhibited T lymphocyte proliferation without affecting B lymphocytes.
  • The inhibitory effect was not attributed to polysaccharide toxicity.
  • Fractions enhanced cell viability and provided protection against oxidative stress in HUVEC and HeLa cells.
  • No significant effect on reactive oxygen species production by granulocytes was observed.

Conclusions:

  • Selenium enrichment significantly increased the biological activity of the tested polysaccharide fractions.
  • Se-enriched polysaccharides show potential for selective immunomodulation and cytoprotective effects.
  • Further research into Se-polysaccharides could yield novel therapeutic agents.