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Checkpoint inhibitor-associated autoimmunity
1McMaster University, Canada.
Best Practice & Research. Clinical Rheumatology
|August 21, 2019
Summary
Checkpoint inhibitors (CI) have transformed cancer treatment but can cause immune-related adverse events (IRAE). This review details IRAE clinical features, management, and impact, highlighting the need for more research.
Area of Science:
- Oncology
- Immunology
- Rheumatology
Background:
- Checkpoint inhibitors (CI) are a cornerstone of modern cancer therapy.
- Immune-related adverse events (IRAE) are a significant challenge associated with CI.
- Understanding and managing IRAE is crucial for patient care.
Purpose of the Study:
- To review the clinical manifestations and management of common and less common IRAE.
- To discuss the mechanism of action of CI and predictors of IRAE.
- To explore the impact of IRAE on cancer treatment outcomes.
Main Methods:
- Review of clinical manifestations and management strategies for IRAE.
- Examination of CI mechanisms and IRAE predictors.
- Analysis of IRAE incidence using meta-analyses of randomized controlled trials.
- Clinical descriptions based on case series and case reports.
Main Results:
- CI have revolutionized cancer management but pose risks of IRAE.
- Common and less common IRAE, including inflammatory arthritis, are discussed.
- Limited prospective studies and treatment trials exist for IRAE.
Conclusions:
- The study of IRAE is still in its early stages.
- Further research, including prospective studies and treatment trials, is essential.
- Clinicians should refer to established guidelines for IRAE management.
Keywords:
Immune checkpoint inhibitorImmune-related adverse eventImmunotherapyInflammatory arthritisMyositisMore Related Videos
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