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Checkpoint inhibitor-associated autoimmunity.

Karim Ladak1, Anne R Bass2

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|August 21, 2019
PubMed
Summary
This summary is machine-generated.

Checkpoint inhibitors (CI) have transformed cancer treatment but can cause immune-related adverse events (IRAE). This review details IRAE clinical features, management, and impact, highlighting the need for more research.

Keywords:
Immune checkpoint inhibitorImmune-related adverse eventImmunotherapyInflammatory arthritisMyositis

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Area of Science:

  • Oncology
  • Immunology
  • Rheumatology

Background:

  • Checkpoint inhibitors (CI) are a cornerstone of modern cancer therapy.
  • Immune-related adverse events (IRAE) are a significant challenge associated with CI.
  • Understanding and managing IRAE is crucial for patient care.

Purpose of the Study:

  • To review the clinical manifestations and management of common and less common IRAE.
  • To discuss the mechanism of action of CI and predictors of IRAE.
  • To explore the impact of IRAE on cancer treatment outcomes.

Main Methods:

  • Review of clinical manifestations and management strategies for IRAE.
  • Examination of CI mechanisms and IRAE predictors.
  • Analysis of IRAE incidence using meta-analyses of randomized controlled trials.
  • Clinical descriptions based on case series and case reports.

Main Results:

  • CI have revolutionized cancer management but pose risks of IRAE.
  • Common and less common IRAE, including inflammatory arthritis, are discussed.
  • Limited prospective studies and treatment trials exist for IRAE.

Conclusions:

  • The study of IRAE is still in its early stages.
  • Further research, including prospective studies and treatment trials, is essential.
  • Clinicians should refer to established guidelines for IRAE management.