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Transcranial Direct Current Stimulation tDCS in Mice
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Adaptive current tDCS up to 4 mA.

Niranjan Khadka1, Helen Borges1, Bhaskar Paneri1

  • 1Department of Biomedical Engineering, The City College of New York, CUNY, New York, NY, 10031, USA.

Brain Stimulation
|August 21, 2019
PubMed
Summary
This summary is machine-generated.

Higher transcranial direct current stimulation (tDCS) currents may improve efficacy, but tolerability is a concern. This study shows adaptive 4mA tDCS is well-tolerated and blinded in healthy subjects, suggesting potential for clinical use.

Keywords:
Adaptive 4 mA tDCSAdaptive controllerTolerability

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Area of Science:

  • Neuroscience
  • Neuromodulation
  • Biomedical Engineering

Background:

  • Transcranial direct current stimulation (tDCS) efficacy may increase with higher currents.
  • Tolerability is a key limitation for higher tDCS intensities.
  • Developing safe and effective high-current tDCS protocols is crucial.

Purpose of the Study:

  • To design and validate electrodes and an adaptive controller for tDCS up to 4mA.
  • To manage tolerability during high-current tDCS using adaptive strategies.
  • To assess the safety, tolerability, and blinding of adaptive 4mA tDCS.

Main Methods:

  • A parallel-group, participant-blind study with 50 healthy subjects.
  • Administered 3 daily 11-minute tDCS sessions using specialized electrodes and a tablet-based stimulator.
  • Compared adaptive 4mA tDCS (with and without participant-controlled 'Relax-mode') to 2mA and sham conditions.

Main Results:

  • Adaptive 4mA tDCS was generally well-tolerated, with few dropouts.
  • Maximum current delivery was observed in the adaptive 4mA with Relax-button condition.
  • VAS pain scores and adverse events were comparable between 2mA and adaptive 4mA tDCS.

Conclusions:

  • Adaptive 4mA tDCS, with specialized electrodes and controllers, is tolerated and effectively blinded.
  • The system demonstrated effective management of current delivery and participant comfort.
  • Findings suggest high-current tDCS may be acceptable in clinical settings, potentially enhanced by simplified controls.