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Updated: Jun 12, 2026

Epigenetic Regulation of Cardiac Differentiation of Embryonic Stem Cells and Tissues
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Challenging the "chromatin hypothesis" of cardiac laminopathies with LMNA mutant iPS cells

Chiara Mozzetta1, Francesco Saverio Tedesco2,3

  • 1Institute of Molecular Biology and Pathology, National Research Council at Sapienza University of Rome, Rome, Italy chiara.mozzetta@uniroma1.it.

The Journal of Cell Biology
|August 21, 2019
PubMed

Keywords:
LMNA mutationscardiac laminopathieschromatin structureinduced pluripotent stem cells

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Chromatin Modification in iPS Cells01:32

Chromatin Modification in iPS Cells

Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
Compact chromatin makes reprogramming difficult. Enzymes, such as histone demethylases and acetyltransferases, are often added during reprogramming to loosen the chromatin, making the DNA more accessible to transcription factors. Molecules that inhibit histone...