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Characterisation of immunogenotypes of diffuse large B-cell lymphoma
K C Phang1, N H Hussin, F Abdul Rahman
1Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Department of Pathology, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000, Kuala Lumpur, Malaysia. noraidah.masir@gmail.com.
The Malaysian Journal of Pathology
|August 21, 2019
Summary
This study found lower germinal center B-cell (GCB) tumor frequency and gene rearrangement rates in Malaysian diffuse large B-cell lymphoma (DLBCL) patients. Further national research is needed to understand DLBCL immunogenetics and survival in Malaysia.
Area of Science:
- Hematology
- Oncology
- Immunogenetics
Background:
- Diffuse large B-cell lymphoma (DLBCL) is an aggressive non-Hodgkin lymphoma with varied outcomes.
- The immunogenotypic landscape of DLBCL in Malaysia remains undercharacterized.
Purpose of the Study:
- To investigate the immunogenotypic features of DLBCL in the Malaysian population.
- To correlate these features with patient survival outcomes.
Main Methods:
- Retrospective analysis of 141 DLBCL cases from UKM Medical Centre.
- Classification of DLBCL subtypes (GCB vs. non-GCB) using Hans and Choi algorithms.
- Fluorescence in situ hybridization (FISH) for gene rearrangements (BCL6, MYC, BCL2).
Main Results:
- A lower frequency of GCB tumors (32.7%) was observed compared to non-GCB (67.3%).
- Significant survival differences were noted between GCB and non-GCB subtypes, elevated LDH, older age, and presence of B symptoms.
- Low rates of gene rearrangements (9.22%), with BCL6 being the most frequent, were found.
Conclusions:
- Malaysian DLBCL cases exhibit a relatively lower GCB tumor frequency and gene rearrangement rates.
- These findings highlight potential regional variations in DLBCL immunogenetics.
- A national study is recommended to further elucidate DLBCL characteristics and survival implications in Malaysia.
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