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Updated: Jan 20, 2026

Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
05:58

Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens

Published on: February 4, 2014

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Solid cancer: the new tumour spread endpoint opens novel opportunities

Michael Fernandes1, Daniel Rosel2, Jan Brábek3

  • 1Medbase, 114 Milton Avenue, Chapel Hill, NC, 27514, USA.

British Journal of Cancer
|August 21, 2019
PubMed

Insights

New androgen deprivation therapies can delay cancer spread in non-metastatic, castration-resistant prostate cancer (nmCRPC). Future drug development will prioritize inhibiting tumor cell migration over proliferation for improved metastasis-free survival.

Area of Science:

  • Oncology
  • Cell Biology
  • Medicinal Chemistry

Background:

  • Novel androgen deprivation agents show promise in delaying metastasis for non-metastatic, castration-resistant prostate cancer (nmCRPC).
  • Recent regulatory guidance emphasizes metastasis-free survival as a key endpoint in clinical trials, opening new research avenues.

Discussion:

  • Previous therapeutic failures may stem from focusing on tumor shrinkage rather than inhibiting tumor spread.
  • Future anti-metastasis drug candidates should be selected based on their anti-migratory potential, not solely anti-proliferative effects.

Key Insights:

  • Metastasis-free survival is a critical endpoint for evaluating novel prostate cancer therapies.
  • Anti-migratory potential is a more relevant metric for anti-metastasis drug efficacy than anti-proliferative activity.
  • Advanced imaging techniques are crucial for monitoring and validating anti-metastasis strategies.

Outlook:

  • Oligometastatic cancer models, combined with advanced imaging, can serve as a clinical proof-of-concept for new anti-metastasis therapies.
  • This paradigm shift will accelerate the development of more effective treatments for advanced prostate cancer.

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