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Updated: Jan 20, 2026
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Method for Obtaining Primary Ovarian Cancer Cells From Solid Specimens
Published on: February 4, 2014
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Solid cancer: the new tumour spread endpoint opens novel opportunities
Michael Fernandes1, Daniel Rosel2, Jan Brábek3
1Medbase, 114 Milton Avenue, Chapel Hill, NC, 27514, USA.
British Journal of Cancer
|August 21, 2019
Summary
New androgen deprivation therapies can delay cancer spread in non-metastatic, castration-resistant prostate cancer (nmCRPC). Future drug development will prioritize inhibiting tumor cell migration over proliferation for improved metastasis-free survival.
Area of Science:
- Oncology
- Cell Biology
- Medicinal Chemistry
Background:
- Novel androgen deprivation agents show promise in delaying metastasis for non-metastatic, castration-resistant prostate cancer (nmCRPC).
- Recent regulatory guidance emphasizes metastasis-free survival as a key endpoint in clinical trials, opening new research avenues.
Discussion:
- Previous therapeutic failures may stem from focusing on tumor shrinkage rather than inhibiting tumor spread.
- Future anti-metastasis drug candidates should be selected based on their anti-migratory potential, not solely anti-proliferative effects.
Key Insights:
- Metastasis-free survival is a critical endpoint for evaluating novel prostate cancer therapies.
- Anti-migratory potential is a more relevant metric for anti-metastasis drug efficacy than anti-proliferative activity.
- Advanced imaging techniques are crucial for monitoring and validating anti-metastasis strategies.
Outlook:
- Oligometastatic cancer models, combined with advanced imaging, can serve as a clinical proof-of-concept for new anti-metastasis therapies.
- This paradigm shift will accelerate the development of more effective treatments for advanced prostate cancer.
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