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Plasma Apelin Unchanged With Acute Exercise Insulin Sensitization.

Justin D Waller1, Emily H McNeill1, Frank Zhong1

  • 1Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, NC, USA.

Journal of Sports Science & Medicine
|August 21, 2019
PubMed
Summary
This summary is machine-generated.

Acute aerobic exercise improves insulin sensitivity, but this effect is independent of changes in apelin levels. This study investigated apelin

Keywords:
Aerobic exerciseHOMA-IRQUICKIglucose challenge

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Area of Science:

  • Exercise Physiology
  • Metabolic Regulation
  • Endocrinology

Background:

  • Mechanisms of post-exercise insulin sensitization are not fully understood.
  • Apelin is known to enhance glucose uptake and insulin sensitivity.
  • The role of apelin in exercise-induced insulin sensitivity is unexplored.

Purpose of the Study:

  • Investigate apelin's response to maximal and submaximal aerobic exercise.
  • Elucidate apelin's influence on insulin sensitivity following acute exercise.

Main Methods:

  • Twelve healthy adults (7 male, 5 female) underwent maximal (VO2max) and submaximal (70-75% VO2max) treadmill exercise and a glucose challenge.
  • Blood samples were collected pre-exercise, post-exercise, 1hr post, and 24hrs post for glucose, insulin, and apelin analysis.
  • Hepatic insulin sensitivity was assessed using HOMA-IR and QUICKI indices.

Main Results:

  • Plasma apelin levels did not significantly change with exercise condition or time.
  • Blood glucose and insulin increased immediately after maximal exercise and glucose challenge, but remained stable after submaximal exercise.
  • Insulin sensitivity significantly improved 1hr post-submaximal exercise (HOMA-IR, QUICKI).
  • Resting plasma apelin correlated with insulin, HOMA-IR, and QUICKI.

Conclusions:

  • Submaximal aerobic exercise enhances hepatic insulin sensitivity 1 hour post-exercise.
  • This exercise-induced insulin sensitization occurs independently of changes in plasma apelin levels.