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Long-Term Control of Metastatic Renal Cell Carcinoma Using Pazopanib

Takashi Kawahara1, Tappei Takeshima1, Yasuhide Miyoshi1

  • 1Departments of Urology and Renal Transplantation, Yokohama City University Medical Center, Yokohama, Japan.

Case Reports in Oncology
|August 21, 2019
PubMed

Insights

Sunitinib and pazopanib showed similar survival outcomes in metastatic renal cell carcinoma. Pazopanib demonstrated better quality of life and early tumor shrinkage, with a case study showing over two years of successful disease control.

Area of Science:

  • Oncology
  • Medical Treatments

Background:

  • The COMPARZ study compared sunitinib and pazopanib for metastatic renal cell carcinoma (mRCC).
  • Renal cell carcinoma is a significant cause of cancer-related mortality.
  • Understanding comparative treatment efficacy and patient-reported outcomes is crucial for mRCC management.

Observation:

  • A 70-year-old male with metastatic renal cell carcinoma (iliac bone and lung metastases) was treated with pazopanib.
  • The patient received pazopanib 800 mg daily for over two years.
  • No abnormal liver function markers were observed during treatment.

Findings:

  • The COMPARZ study found no significant differences in progression-free survival or overall survival between sunitinib and pazopanib.
  • Pazopanib demonstrated superior outcomes in early tumor shrinkage and quality of life compared to sunitinib.
  • The case study illustrated successful, long-term (over two years) disease control in metastatic renal cell carcinoma with pazopanib, with notable reduction in lung metastasis size and number.

Implications:

  • Pazopanib offers a favorable alternative to sunitinib for metastatic renal cell carcinoma, particularly regarding quality of life and early tumor response.
  • Long-term pazopanib treatment can achieve durable disease control in select metastatic renal cell carcinoma patients.
  • These findings support personalized treatment strategies in metastatic renal cell carcinoma, considering both survival and patient-centered outcomes.
Keywords:
Metastatic renal cell carcinomaNivolumabPazopanib

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