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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

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Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
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Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

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The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
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Related Experiment Video

Updated: Jan 20, 2026

Acupuncture in a Rat Model of Asthma
07:14

Acupuncture in a Rat Model of Asthma

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Sestrin2 is involved in asthma: a case-control study.

Yanfang Kang1,2, Chen Chen3, Xiaotian Hu2

  • 11Department of Respiratory and Critical Care Medicine, First Affiliated Hospital Kunming Medical University, No.295, Xichang Road, Wuhua District, Kunming, China.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|August 21, 2019
PubMed
Summary

Sestrin2 levels are elevated in asthma patients, correlating with reduced lung function. This suggests sestrin2 plays a role in asthma and may be a marker for disease severity.

Keywords:
AsthmaInflammationOxidative stressSestrin2

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Area of Science:

  • Biochemistry
  • Pulmonology
  • Oxidative Stress Research

Background:

  • Asthma is a chronic respiratory disease significantly impacting patient health.
  • Oxidative stress is a known factor in asthma pathogenesis.
  • Sestrin2, an oxidative stress-inducible protein, is implicated in related diseases.

Purpose of the Study:

  • To investigate the involvement of sestrin2 in asthma.
  • To determine sestrin2 levels in asthma patients compared to controls.
  • To explore the relationship between sestrin2 and lung function parameters in asthma.

Main Methods:

  • Recruited 76 subjects (44 asthma, 32 control).
  • Measured plasma sestrin2 levels, peak expiratory flow (PEF), forced expiratory volume in 1 second (FEV1)% predicted, forced vital capacity (FVC)% predicted, and FEV1/FVC ratio.
  • Assessed parameters in asthmatics during exacerbation and after control, and in healthy controls.

Main Results:

  • Asthma patients exhibited significantly higher plasma sestrin2 levels than controls, both during exacerbation and when controlled.
  • Sestrin2 levels negatively correlated with FEV1% predicted and FEV1/FVC ratio in asthmatics.
  • Multiple linear regression confirmed sestrin2 is independently associated with FEV1% predicted in asthma.

Conclusions:

  • Sestrin2 is implicated in asthma pathogenesis.
  • Elevated sestrin2 levels are observed in asthma patients irrespective of exacerbation status.
  • Sestrin2 is an independent predictor of lung function (FEV1% predicted) in asthma.