Related Experiment Video
Updated: Jan 20, 2026

3D Organotypic Co-culture Model Supporting Medullary Thymic Epithelial Cell Proliferation, Differentiation and Promiscuous Gene Expression
Published on: July 30, 2015
Data structures for compound promiscuity analysis: promiscuity cliffs, pathways and promiscuity hubs formed by
Filip Miljković1, Jürgen Bajorath1
1Department of Life Science Informatics, B-IT, LIMES Program Unit Chemical Biology & Medicinal Chemistry, Rheinische Friedrich-Wilhelms-Universität, Endenicher Allee 19c, D-53115 Bonn, Germany.
Aim:
A large collection of promiscuity cliffs (PCs), PC pathways (PCPs) and promiscuity hubs (PHs) formed by inhibitors of human kinases is made freely available.
Methodology:
Inhibitor PCs were systematically identified and organized in network representations, from which PCPs were extracted. PH compounds were classified and their neighborhoods analyzed.
Data & Exemplary Results:
Nearly 16,000 PCs covering the human kinome were identified, which yielded more than 600 PC clusters and 8900 PCPs. Moreover, 520 PHs were obtained.
Limitations & Next Steps:
PC and PCP data structures capture structure-promiscuity relationships. Promiscuity assessment is also affected by data sparseness. Given the rapid growth of kinase inhibitor data, the relevance of PC/PCP/PH information for medicinal chemistry and chemical biology applications will further increase.
More Related Videos
07:55An Optimized Quantitative Pull-Down Analysis of RNA-Binding Proteins Using Short Biotinylated RNA
Published on: February 17, 2023
07:42Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
Published on: September 19, 2018
Related Concept Videos
Lewis Structures of Molecular Compounds and Polyatomic Ions
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...
Organic Compounds
Compounds Essential to Human Function
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
Classification of Elements and Compounds
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
Molecules and Compounds