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Updated: Jan 20, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
Relationship of growth differentiation factor-15 with aortic stiffness in essential hypertension
Erdoğan Sökmen1, Cahit Uçar2, Serkan Sivri1
1Department of Cardiology, Kirsehir Ahi Evran University Training & Research Hospital, Kirsehir, Turkey.
Aim:
We aimed to assess the relationship between echocardiographic parameters of aortic elasticity, namely aortic strain, aortic distensibility and aortic β-index, and serum growth differentiation factor (GDF)-15 in patients with newly diagnosed essential hypertension (HT).
Methods:
Grade-1 HT patients (n = 50), grade-2 HT (n = 70) patients and 35 healthy controls were included.
Results:
GDF-15 was greater in grade-2 HT group compared with the other groups. All aortic elasticity parameters were worse in grade-2 HT group compared with the other groups. GDF-15 correlated positively with E/E' ratio (the ratio of transmitral E velocity to mean diastolic mitral annular velocity) and β-index; and aortic strain and aortic distensibility correlated negatively with serum GDF-15. β-index, aortic diastolic diameter and diastolic blood pressure were independently associated with GDF-15.
Conclusion:
GDF-15 may be utilized in the prediction of increased aortic stiffness.
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