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Rituximab as Rescue Therapy for Aggressive Pediatric Multiple Sclerosis

George Vartzelis1, Despoina Maritsi1, Maria Nikolaidou1

  • 1Second Department of Pediatrics, National and Kapodistrian University of Athens, Medical School, "P. & A. Kyriakous" Children's Hospital, Athens, Greece.

Case Reports in Pediatrics
|August 21, 2019
PubMed

Insights

Rituximab offers a promising treatment for pediatric multiple sclerosis (MS). This therapy effectively induced remission in a young boy with severe, treatment-refractory MS.

Area of Science:

  • Neurology
  • Immunology
  • Pediatrics

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease with limited pediatric treatment options.
  • Pediatric MS affects nearly 10% of MS patients, necessitating effective therapies.
  • Rituximab, an anti-CD20 antibody, depletes CD20+ lymphocytes and is an emerging therapy.

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