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Published on: June 25, 2018
Ti3C2 MXene as a novel substrate provides rapid differentiation and quantitation of glycan isomers with LDI-MS
Yuming Jiang1, Jie Sun, Yi Cui
1Beijing National Laboratory for Molecular Sciences, Key Laboratory for Analytical Chemistry for Living Biosystems, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China. znie@iccas.ac.cn.
Abstract:
Here we report Ti3C2 MXene assisted LDI-LIFT-TOF/TOF for robust differentiation and relative quantitation of glycan isomers that differ in composition, connectivity and configuration. The improved sensitivity and background-free properties of this substrate combined with the special fragment profile produced by LDI-LIFT-TOF/TOF open a new door for nanomaterial assisted glycan structual analysis.
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