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Group Design02:01

Group Design

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The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
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Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
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When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
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Trapezoidal channels are widely used in irrigation systems due to their cost-effectiveness and efficiency in conveying water. Trapezoidal channels feature a flat bottom and sloping sides, making them stable and easier to construct compared to other shapes. The bottom width and side slope ratio are determined based on the required flow capacity and site conditions. The side slope is kept gentle for unlined channels to prevent soil erosion.Hydraulic parameters in channel design include the flow...
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Design Example01:23

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A novel micro drill design based on Ros-DrillⒸ.

Handan Nak1, Ali Fuat Ergenc2

  • 1Control and Automation Engineering Department, Istanbul Technical University, Sariyer, Turkey. handan.nak@itu.edu.tr.

Biomedical Microdevices
|August 21, 2019
PubMed
Summary

A new mercury-free micro drill device was developed for biological applications. This novel tool enhances microinjection and biopsy success rates in living organisms without the toxicity risks associated with mercury.

Keywords:
BLDC motorC. elegans worm injectionICSIMicro drillRotational oscillations

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Area of Science:

  • Biomedical Engineering
  • Microtechnology
  • Cell Biology

Background:

  • Current microinjection techniques often utilize mercury, posing toxicity risks to operators and cells.
  • The need for safer, mercury-free alternatives in micro-manipulation is critical for biological research and medical procedures.

Purpose of the Study:

  • To develop and present a novel, mercury-free micro drill device for precise manipulation of single living organisms.
  • To offer a safer alternative to existing microinjection methods, improving success rates and usability.

Main Methods:

  • Development of a micro drill device driven by a brushless motor, incorporating a micropipette holder.
  • Utilizing a rotational piercing approach, similar to the Ros-Drill principle, with adjustable oscillation amplitude and frequency.
  • Testing the device's efficacy in microinjection and biopsy procedures on various organisms.

Main Results:

  • The novel micro drill demonstrated suitability for microinjection and biopsy tasks across different organisms.
  • Achieved high success rates, ease of use, and a compact design.
  • Confirmed compatibility with diverse manipulation systems, highlighting its versatility.

Conclusions:

  • The developed mercury-free micro drill offers a safe and effective solution for micro-manipulation in biological research.
  • The device's performance, usability, and adaptability make it a valuable tool for advancing techniques like microinjection and biopsy.